Tracheal Responsiveness to Histamine and Histamine (H1) Receptor Blockade by Chlorpheniramine in an Animal Model of COPD
نویسندگان
چکیده
منابع مشابه
INCREASED HISTAMINE Hi RECEPTOR BLOCKADE BY CHLORPHENIRAMINE IN TRACHEAL CHAINS OF ASTHMATIC GUINEA PIGS
Receptor affinity and drug delivery to the receptor sites could be determinant factors for the increased bronchial responsiveness seen in asthma. Competitive antagonism blockade which is measured as dose ratio-l (DR-I) depends only on these two factors. Therefore, in this study we have examined histamine HI blockade by chlorpheniramine on isolated tracheal chains of asthmatic compared to co...
متن کاملEffects of chlorpheniramine (histamine H1 receptor antagonist) on food and water intake in broiler chickens in hunger and satiety
The role of histamine in the regulation of food and water intake in mammals and birds of the review, this study evaluated the effects of intraperitoneal administration of chlorpheniramine as histamine H1-receptor antagonist, in broiler chicks on feed intake and satiety in water and was hungry. 32 male Ross broiler chicks reared in groups of four weeks, 16 samples (control and test) were then in...
متن کاملEffects of chlorpheniramine (histamine H1 receptor antagonist) on food and water intake in broiler chickens in hunger and satiety
The role of histamine in the regulation of food and water intake in mammals and birds of the review, this study evaluated the effects of intraperitoneal administration of chlorpheniramine as histamine H1-receptor antagonist, in broiler chicks on feed intake and satiety in water and was hungry. 32 male Ross broiler chicks reared in groups of four weeks, 16 samples (control and test) were then in...
متن کاملEffects of chlorpheniramine and hydroxyzine administration, as histamine H1- receptor antagonists, on the nociception threshold of cholestatic rats
Introduction: The elevated endogenous opioid tone in cholestasis is associated with changes including an increase in the nociception threshold. We aimed to study the effect of chlorpheniramine and hydroxyzine, H1-receptor antagonists, on modulation of nociception in a model of elevated endogenous opioid tone, cholestasis. Methods: Cholestasis was induced by ligation of main bile duct using ...
متن کاملConjunctival eosinophil infiltration evoked by histamine and immediate hypersensitivity. Modification by H1- and H2-receptor blockade.
The present histological studies have demonstrated that histamine causes dose-dependent eosinophil infiltration into the conjunctiva. A highly directional movement toward the conjunctival epithelium was observed, and the presence of large numbers of degranulating eosinophils appeared to result in epithelial cell damage and goblet cell discharge. Blockade of H2-receptors by systemic cimetidine p...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: International Journal of Pharmacology
سال: 2005
ISSN: 1811-7775
DOI: 10.3923/ijp.2005.350.356